Molecule of the Month June 2018 |
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Metallocene Binding to Oligonucleotides | ||
Metallocenes and their derivatives are promising anticancer drug candidates targeting nucleic acids. Information on the precise binding modes and preferred binding sites is still scarce. Tandem mass spectrometry constitutes a versatile method for the structural characterization of titanocene-oligonucleotide adducts.
This work was carried out by Rahel Eberle in the group of Prof. Dr. Stefan Schürch. References:
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