Molecule of the Month March 2004 |
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Design and Synthesis of Small Drug-Like Molecules | ||
Diversity-oriented oligomerization of hydroxyaromatic aldehydes and ketones by oxime and ether bond formation leads to a diversity of drug-like molecules. The crystal structure of an ether oligomer is shown above. Micromolar inhibitors of proteases were readily discovered in a 140-member library. These new class of compounds are promising leads for drug discovery. This work was carried out in the group of Prof. Jean-Louis Reymond. References:
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