Molecule of the Month February 2004 |
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A Comparison of Tricyclo-DNA with LNA | ||
In a cellular assay we found that tricyclo-DNA acts as a more powerful antisense oligonucleotide in the splice-shifting of CyPA pre-mRNA compared to LNA, which is the world’s strongest RNA binder known today. The increased efficacy of tricyclo-DNA can not be attributed to higher RNA affinity, but more likely to a more favorable nuclear distribution. This work was carried out in the group of Prof. Christian Leumann. References:
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