Molecule of the Month
|Globoside is an Essential Intracellular Binding Partner Required for B19 Virus Infectious Entry|
Individuals lacking globoside are resistant to parvovirus B19 (B19V) infection. We have revealed the mechanism of the interaction between B19V and globoside. pH acts as a switch prohibiting the interaction on the plasma membrane and promoting it inside acidic endosomal compartments, where the glycosphingolipid is essential for the infectious trafficking of the virus.
This work was carried out in the group of PD Dr. Carlos Ros.