Molecule of the Month
|Re-Thinking the Bonding Mode of Histidine in Metalloenzymes|
In metalloenzymes, histidine is typically assumed to bind to metals via a nitrogen atom. We investigated the carbon-bonding mode in the small Cu-protein azurin from P. aeruginosa and, for the first time, demonstrated the implication of such C-bonding by using an N-heterocyclic carbene as a surrogate for C-bound histidine.
This work was carried out in the group of Prof. Martin Albrecht.