Molecule of the Month
|DNA Duplexes in the Gas-Phase|
Tandem mass spectrometry is evaluated to study the stability of higher-order structures of biomolecules in the gas-phase. Upon collisional activation, DNA:DNA duplexes dissociate via strand separation. For highly modified nucleic acids, by contrast, the ejection of backbone fragments from the duplex presents an alternative fragmentation channel accessible at similar activation energies.
This work was carried out in the group of PD Dr. Stefan Schürch.