Molecule of the Month
|Discovery of a Selective TRPV6 Inhibitor by Virtual Screening|
A pharmacophore similarity algorithm called xLOS was used in combination with chemical synthesis to entirely change the scaffold of a weak, unselective inhibitor of calcium channel TRPV6 to obtain a potent, selective inhibitor. Inhibition of TRPV6 selectively reduced cancer cell growth.
This work was carried out in the group of Prof. Jean-Louis Reymond.