Molecule of the Month November 2015 |
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Discovery of a Selective TRPV6 Inhibitor by Virtual Screening | ||
A pharmacophore similarity algorithm called xLOS was used in combination with chemical synthesis to entirely change the scaffold of a weak, unselective inhibitor of calcium channel TRPV6 to obtain a potent, selective inhibitor. Inhibition of TRPV6 selectively reduced cancer cell growth.
This work was carried out in the group of Prof. Jean-Louis Reymond. References:
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