Molecule of the Month June 2012 |
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A Lipophilic Derivative of Tricyclo-DNA | ||
To improve the cellular uptake of tricyclo-DNA (tc-DNA), an oligonucleotide analog with promising activity in antisense and siRNA-based therapies, a palmityl ester was appended to the structure of tc-DNA.
This work was carried out by Jory Liétard in the group of Prof. Christian Leumann. References:
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