A 15'625-member peptide dendrimer combinatorial library was acylated with an a-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC₅₀ = 11 µM) and Pseudomonas aeruginosa lectin PA-IIL (IC₅₀ = 0.14 µM).
The dendrimer might be therapeutically useful for cystic fibrosis patients.

This work was carried out in the group of Prof. Jean-Louis Reymond.

References:

• E. Kolomiets, E. M. V. Johansson, O. Renaudet, T. Darbre, J.-L. Reymond;
  "Neoglycopeptide Dendrimer Libraries as a Source of Lectin Binding Ligands."
  Org. Lett., 9, 1465-1468, (2007); doi:10.1021/ol070119d.