Molecule of the Month
January 2017
Membrane Protein Delivery into Giant Vesicles Using Charged‑Mediated Fusion

Mulitple proteins embedded in small positively charged liposomes were delivered into the membranes of negatively charged giant unilamellar vesicles by charged mediated fusion. The process occurs within a few minutes and was verified by functional analysis of the proteins and fluorescence microscopy.

This work was carried out in the group of Christoph von Ballmoos.

References:

  • O. Biner, T. Schick, Y. Müller, C. von Ballmoos;
    "Delivery of membrane proteins into small and giant unilamellar vesicles by charge-mediated fusion"
    FEBS Letters, 2016, 590(14), 2047; doi:10.1002/1873-3468.12302   &
    FEBS Letters, 2016, 590(14), 2051-2062; doi:10.1002/1873-3468.12233.